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| Product Category: | Knockdown Validated Polyclonal Antibody |
| Synonyms: | Proliferating Cell Nuclear Antigen; Cyclin; DNA Polymerase Delta Auxiliary Protein; ATLD2 |
| UniProt Entry: | P12004 |
| NCBI Gene Entry: | 5111 |
| Molecular Weight: | 36 kDa |
| Clonality: | Rabbit polyclonal antibody |
| Species Reactivity: | Human |
| Applications: | WB/IC/F |
| Recommended Dilution: | WB 1:1000 / IC 1:200 / F 1:100 |
| Immunogen: | Recombinant fragment of human PCNA |
| Isotype: | Rabbit IgG |
| Storage Buffer: | Supplied in PBS (pH 7.5) containing 50 µg/ml BSA, 50% glycerol, and 0.01% sodium azide |
| Storage: | At –20°C |
| Background: | Proliferating Cell Nuclear Antigen,commonly known as PCNA,is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. PCNA induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase,but not apurinic-apyrimidinic (AP) endonuclease,APEX2 activities. It has to be loaded onto DNA in order to be able to stimulate APEX2. PCNA protein is highly conserved during evolution; the deduced amino acid sequences of rat and human differ by only 4 of 261 amino acids. PCNA has been used as loading control for proliferating cells. |
| Documents: | Please contact us to request the manual |
